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Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 327-334 doi: 10.1007/s11684-019-0712-x

Abstract: This study aimed to investigate the prevalence, clinical characteristics, and prognostic impact of 1p32.3), gain(1q21), del(17p13), del(13q14), t(4;14), and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly moreMultivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFSPatients with del(1p32.3) under bortezomib-based treatments tended to have short PFS and OS.

Keywords： 1p32.3 deletion     1q21 gain     prognosis     multiple myeloma     FISH     bortezomib     thalidomide    

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 489-495 doi: 10.1007/s11465-019-0554-x

Abstract: Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which isIn this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °CThe computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing mapsQ345R bimetal.Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature

Keywords： BTW1/Q345R bimetal     constitutive equation     processing map     work hardening    

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Preparation of ultrathin ReS2 nanosheets and their application to Q-switched Er-doped fiber Research

Junshan He, Guohua Zeng, Shaoxian Liu, Haiming Lu, Ruixian Xie, Jingjing Qi, Lili Tao, Bo Zhou,taoll@gdut.edu.cn,zhoubo@scut.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 3,   Pages 287-436 doi: 10.1631/FITEE.2000339

Abstract: study the exfoliation of ultrathin ReS nanosheets from the prepared ReS powder and their application to Q-switchedduration of 2.4 μs and an output power of 1.25 mW are obtained, indicating the potential application to Q-switched

Keywords： 二硫化铼；可饱和吸收体；二维材料；调Q光纤激光器    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinase1 (PAK1), a member of a serine/threonine protein kinase family.Despite the large body of evidence from studies in noncardiac tissue indicating that PAK1 activity iskey in the regulation of a number of cellular functions, the role of PAK1 in the heart has only beenWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy withTwo leukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21In this study, 85 patients with t(8;21) AML were enrolled.CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidtherapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21HHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thusThe combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival.indicating that their combination may be an effective therapy for t(8; 21) leukemia.

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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Sb2Te3 topological insulator for 52 nm wideband tunable Yb-doped passively Q-switched Research

Tao Wang, Qiang Yu, Kun Guo, Xinyao Shi, Xuefen Kan, Yijun Xu, Jian Wu, Kai Zhang, Pu Zhou,wujian15203@163.com,kzhang2015@sinano.ac.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 3,   Pages 287-436 doi: 10.1631/FITEE.2000577

Abstract: saturable absorber (SA) of the family was first applied experimentally in a wideband tunable passively Q-switchedMeanwhile, stable wavelength-tunable passive Q-switching pulse operation was obtained in a Yb-doped fiber

Keywords： 拓扑绝缘体；Sb2Te3；光纤激光；被动调Q激光；波长可调谐激光    

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Minimax Q-learning design for H∞ control of linear discrete-time systems Research Articles

Xinxing LI, Lele XI, Wenzhong ZHA, Zhihong PENG,lixinxing_1006@163.com,xilele.bit@gmail.com,zhawenzhong@126.com,peng@bit.edu.cn

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 3,   Pages 438-451 doi: 10.1631/FITEE.2000446

Abstract: The method is an effective approach for attenuating the effect of disturbances on practical systems, but it is difficult to obtain the ler due to the nonlinear Hamilton–Jacobi–Isaacs equation, even for linear systems. This study deals with the design of an ler for linear discrete-time systems. To solve the related game algebraic Riccati equation (GARE), a novel model-free method is developed, on the basis of an offline algorithm, which is shown to be Newton’s method for solving the GARE. The proposed method, which employs off-policy , learns the optimal control policies for the controller and the disturbance online, using only the state samples generated by the implemented behavior policies. Different from existing -learning methods, a novel gradient-based policy improvement scheme is proposed. We prove that the method converges to the saddle solution under initially admissible control policies and an appropriate positive learning rate, provided that certain persistence of excitation (PE) conditions are satisfied. In addition, the PE conditions can be easily met by choosing appropriate behavior policies containing certain excitation noises, without causing any excitation noise bias. In the simulation study, we apply the proposed method to design an load-frequency controller for an electrical power system generator that suffers from load disturbance, and the simulation results indicate that the obtained load-frequency controller has good disturbance rejection performance.

Keywords： H∞ control     Zero-sum dynamic game     Reinforcement learning     Adaptive dynamic programming     Minimax Q-learning    

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Gain-enhanced reconfigurable radiation array with mechanically driven system and directive elements

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0716-0

Abstract: radiation array (RRA) based on miniaturized elements and a mechanically reconfigurable system to obtain gain-enhanced

Keywords： mechanism     reconfigurable radiation array (RRA)     compact state     deployed state     enhanced gain    

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Learning natural ordering of tags in domain-specific Q&A sites

Junfang Jia, Guoqiang Li,jiajunfang816@163.com,li.g@sjtu.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 2,   Pages 141-286 doi: 10.1631/FITEE.1900645

Abstract: In this paper, we focus on the ing of tags in domain-specific Q&A sites.We study tag sequences of millions of questions in four Q&A sites, i.e., CodeProject, SegmentFault, BiostarsOur results show that users of these Q&A sites can develop implicit consensus about in which order theyOur study opens the path to improve existing tag recommendation and Q&A site navigation by leveraging

Keywords： Question and answering (Q&     A) sites     Tagging     Natural order     Skip gram    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesispathogenetic insights that have been gained from identifying the various events that can cooperate with AML1-We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting theRecently published studies suggest that a targeted therapy for t(8;21) positive AML is feasible and may

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

Keywords： JH classification     Q and RMR classification     new method    

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A reversibility-gain model for integer Karhunen-Loève transform design in video coding

Xing-guo ZHU,Lu YU

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 10,   Pages 883-891 doi: 10.1631/FITEE.1500071

Abstract: In this paper, a joint reversibility-gain (R-G) model is proposed for integer-KLT design in video codingThe ‘gain’ means transform coding gain (TCG), which is a widely used criterion for transform design inmaximizes the TCG under some assumptions, here we define the TCG loss ratio (LR) to measure how much coding gain

Keywords： Integer transform     Karhunen-Loè     ve transform (KLT)     Integer-KLT     Transform coding     Video coding    

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An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 1,   Pages 26-35 doi: 10.1007/s11709-014-0239-9

Abstract: To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the loadbearing capacity of high strength Q460 steel columns is investigated.evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460steel columns with due consideration to high temperature properties of high strength Q460 steel.The critical temperature of high strength Q460 steel column is presented and compared with mild steel

Keywords： high strength Q460 steel     load bearing capacity     temperature    

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Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 16-21

Abstract:

In the light of the mentioned above, the forest remote sensing perspective of the 21 st century

1 To include all kinds of new technology and form new technology system and join up with international

Keywords： forestry     remote sensing     developing of sustainable forestry     forestry towards the 21 st century    

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Title Author Date Type Operation

Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence

Huanping Wang, Haitao Meng, Jinghan Wang, Yinjun Lou, Yile Zhou, Peipei Lin, Fenglin Li, Lin Liu, Huan Xu, Min Yang, Jie Jin

Journal Article

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Journal Article

Preparation of ultrathin ReS2 nanosheets and their application to Q-switched Er-doped fiber

Junshan He, Guohua Zeng, Shaoxian Liu, Haiming Lu, Ruixian Xie, Jingjing Qi, Lili Tao, Bo Zhou,taoll@gdut.edu.cn,zhoubo@scut.edu.cn

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

Sb2Te3 topological insulator for 52 nm wideband tunable Yb-doped passively Q-switched

Tao Wang, Qiang Yu, Kun Guo, Xinyao Shi, Xuefen Kan, Yijun Xu, Jian Wu, Kai Zhang, Pu Zhou,wujian15203@163.com,kzhang2015@sinano.ac.cn

Journal Article

Minimax Q-learning design for H∞ control of linear discrete-time systems

Xinxing LI, Lele XI, Wenzhong ZHA, Zhihong PENG,lixinxing_1006@163.com,xilele.bit@gmail.com,zhawenzhong@126.com,peng@bit.edu.cn

Journal Article

Gain-enhanced reconfigurable radiation array with mechanically driven system and directive elements

Journal Article

Learning natural ordering of tags in domain-specific Q&A sites

Junfang Jia, Guoqiang Li,jiajunfang816@163.com,li.g@sjtu.edu.cn

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

A reversibility-gain model for integer Karhunen-Loève transform design in video coding

Xing-guo ZHU,Lu YU

Journal Article

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

Journal Article

Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Journal Article